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SIR2-LIKE PROTEINS
Descriptors Found:
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DeCS
Descriptor
English
:
Sirtuins
Descriptor
Spanish
:
Sirtuinas
Descriptor
Portuguese
:
Sirtuínas
Synonyms
English
:
Silent Mating Type Information Regulator 2-like Proteins
Silent Mating Type Information Regulator 2 like Proteins
Sir2 like Proteins
Sir2-like Proteins
Tree Number:
D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
Definition
English
:
A homologous
family
of regulatory
enzymes
that are structurally related to the protein silent mating type
information
regulator 2 (Sir2) found in
Saccharomyces cerevisiae
.
Sirtuins
contain a central catalytic core region which binds NAD. Several of the
sirtuins
utilize NAD to deacetylate
proteins
such as
HISTONES
and are categorized as
GROUP III HISTONE DEACETYLASES
. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to
proteins
and are categorized as MONO ADP-RIBOSE
TRANSFERASES
, while a third group of
sirtuins
appears to have both deacetylase and ADP
ribose
transferase
activities.
See Related
English
:
Silent Information Regulator Proteins, Saccharomyces cerevisiae
History Note
English
:
2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37322
Unique Identifier:
D037761
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS